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Homer1tm1Mhd
Targeted Allele Detail
Nomenclature
Symbol: Homer1tm1Mhd
Name: homer scaffolding protein 1; targeted mutation 1, Marlin H Dehoff
MGI ID: MGI:3526529
Synonyms: H1ko
Gene: Homer1  Location: Chr13:93303757-93404129 bp, + strand  Genetic Position: Chr13, 47.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95212
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsOne loxP site was inserted 200 bp upstream of exon 2 and an SV40-neo cassette flanked with frt sites and containing an additional loxP site was inserted 700 bp downstream of exon 2. The neomycin insert was subsequently removed by crossing to Flpe transgenic mice after which exon 2 was excised by crossing to CMV-cre transgenic mice. (J:95212)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Homer1 Mutation:  11 strains or lines available
References
Original:  J:95212 Yuan JP, et al., Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003 Sep 19;114(6):777-89
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory