About   Help   FAQ
Targeted Allele Detail
Symbol: Homer1tm1Mhd
Name: homer scaffolding protein 1; targeted mutation 1, Marlin H Dehoff
MGI ID: MGI:3526529
Synonyms: H1ko
Gene: Homer1  Location: Chr13:93303757-93405129 bp, + strand  Genetic Position: Chr13, 47.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:95212
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsOne loxP site was inserted 200 bp upstream of exon 2 and an SV40-neo cassette flanked with frt sites and containing an additional loxP site was inserted 700 bp downstream of exon 2. The neomycin insert was subsequently removed by crossing to Flpe transgenic mice after which exon 2 was excised by crossing to CMV-cre transgenic mice. (J:95212)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Homer1 Mutation:  15 strains or lines available
Original:  J:95212 Yuan JP, et al., Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003 Sep 19;114(6):777-89
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory