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Spred1tm1Hiin
Targeted Allele Detail
Nomenclature
Symbol: Spred1tm1Hiin
Name: sprouty protein with EVH-1 domain 1, related sequence; targeted mutation 1, Hiromasa Inoue
MGI ID: MGI:3526452
Synonyms: Spred-1-
Gene: Spred1  Location: Chr2:117121374-117182279 bp, + strand  Genetic Position: Chr2, 59.03 cM, cytoband E5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95263
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced much of exon 4, including the sequence encoding the kit-binding domain and Sprouty-related COOH-terminal cystein-rich domains. RT-PCR confirmed the lack of transcript in mutant brain samples, and Western blot showed the lack of protein in mutant brain, liver, and kidney samples. (J:95263)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spred1 Mutation:  29 strains or lines available
References
Original:  J:95263 Inoue H, et al., Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. J Exp Med. 2005 Jan 3;201(1):73-82
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory