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Targeted Allele Detail
Symbol: Apex2tm1Yun
Name: apurinic/apyrimidinic endonuclease 2; targeted mutation 1, Yusaku Nakabeppu
MGI ID: MGI:3526443
Gene: Apex2  Location: ChrX:150519519-150589868 bp, - strand  Genetic Position: ChrX, 68.46 cM, cytoband F2
Germline Transmission:  Earliest citation of germline transmission: J:95267
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace the 3' end of intron 5 and the 5' end of exon 6 with a neo in the opposite orientation. Northern blot showed that mutant ES cells did not contain wild-type transcript. (J:82005)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apex2 Mutation:  4 strains or lines available
Original:  J:95267 Ide Y, et al., Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood. 2004 Dec 15;104(13):4097-103
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory