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Targeted Allele Detail
Symbol: Slc9a3r1tm1Geo
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; targeted mutation 1, Maria-Magdelena Georgescu
MGI ID: MGI:3526430
Synonyms: EBP50-
Gene: Slc9a3r1  Location: Chr11:115163341-115181178 bp, + strand  Genetic Position: Chr11, 80.65 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:95282
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exons 1-4, which contain most of the coding sequence, with a neo gene lacking the polyadenlylation sequence. RT-PCR and sequencing revealed that exons 5 and 6 were transcribed after the stop codon of the neo mRNA, as part of the 3' UTR. Absence of protein from exons 5 and 6 was further confirmed by Western blot analysis of kidneys from mutant animals. (J:95282)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc9a3r1 Mutation:  15 strains or lines available
Original:  J:95282 Morales FC, et al., Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17705-10
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory