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Ctsgtm2.1(PML/RARA)Ley
Targeted Allele Detail
Nomenclature
Symbol: Ctsgtm2.1(PML/RARA)Ley
Name: cathepsin G; targeted mutation 2.1, Timothy J Ley
MGI ID: MGI:3526413
Synonyms: Ctsgtm2.1Ley, mCGPML-RARalpha, mCGPR(deltaPGK-neo), PRWT
Gene: Ctsg  Location: Chr14:56099881-56102574 bp, - strand  Genetic Position: Chr14, 28.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84230
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Ctsgtm2.1(PML/RARA)Ley expresses 2 genes
 
Mutation detailsA human cDNA encoding the PML-RARalpha fusion and a loxP flanked PGK-neo was inserted into the 5' UTR. Transient Cre expression removed the floxed PGK-neo. (J:84230)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsg Mutation:  3 strains or lines available
References
Original:  J:84230 Westervelt P, et al., High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. Blood. 2003 Sep 1;102(5):1857-65
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory