Fgf3^tm1Sms
Targeted Allele Detail

Summary

• Symbol: Fgf3^tm1Sms
• Name: fibroblast growth factor 3; targeted mutation 1, Suzanne L Mansour
• MGI ID: MGI:3526179
• Gene: Fgf3 Location: Chr7:144392349-144397085 bp, + strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fgf3^tm1Sms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128377
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An construct containing tetracycline response elements and an frt flanked PGKNeobpA+KanR was inserted into intron 1. In addition, exon 2 was flanked by loxP sites. (J:128377)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf3 Mutation: 16 strains or lines available

References

• Original: J:128377 Hatch EP, et al., Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007 Oct;134(20):3615-25
• All: 2 reference(s)