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Targeted Allele Detail
Symbol: Dusp6tm1Sms
Name: dual specificity phosphatase 6; targeted mutation 1, Suzanne L Mansour
MGI ID: MGI:3526178
Synonyms: Dusp6L
Gene: Dusp6  Location: Chr10:99099093-99103351 bp, + strand  Genetic Position: Chr10, 51.13 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:117073
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZtAceCreNeo cassette was inserted in frame into exon 1 and a stop codon was placed in exon 3. The tAceCreNeo cassette was automatically excised during germline transmission of the mutant allele. Northern blot analysis confirmed the absence of transcription. Expression of LacZ is very low or absent in heterozygotes but present in homozygotes. (J:117073)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dusp6 Mutation:  19 strains or lines available
Original:  J:117073 Li C, et al., Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development. Development. 2007 Jan;134(1):167-76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory