Mtrr^Gt(XG334)Byg
Gene trapped Allele Detail

Summary

• Symbol: Mtrr^Gt(XG334)Byg
• Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; gene trap XG334, BayGenomics
• MGI ID: MGI:3526159
• Synonyms: Mtrr^gt, Mtrr^{Gt(pGT1Lxf)1Rgma}, Mtrr^{Gt(pGT1Lxf)1Ucd}
• Gene: Mtrr Location: Chr13:68708899-68730268 bp, - strand Genetic Position: Chr13, 35.54 cM
• Alliance: Mtrr^Gt(XG334)Byg page

Mutation origin

• Mutant Cell Line: XG334
• Germline Transmission: Earliest citation of germline transmission: J:121477
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf
• Mutation details: pGT1Lxf, containing En2 intron/exon with splice acceptor, beta-galactosidase and neomycin resistance cassettes (beta-geo), and SV40 polyA site and ampicillin resisitance, 41.0 cM, pGT1Lxf insertion in intron 9, betwee exons 9 and 10. Inserted exactly 398 bp downstream of exon 9 and approximately 1.5 Kb upstream of exon 10. (J:121477)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XG334	CC183121 ; (MGI Seq Detail)	5' RACE	Chr13:68716891-68720820 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  45 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	36 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mtrr Mutation: 45 strains or lines available

References

• Original: J:121477 Elmore CL, et al., Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab. 2007 May;91(1):85-97
• All: 14 reference(s)