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Chrna2tm1Jbou
Targeted Allele Detail
Nomenclature
Symbol: Chrna2tm1Jbou
Name: cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); targeted mutation 1, Jim Boulter
MGI ID: MGI:3526149
Synonyms: alpha2-
Gene: Chrna2  Location: Chr14:66135039-66152948 bp, + strand  Genetic Position: Chr14, 34.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126075
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted in exon 5. The presence of the null allele was confirmed by genomic PCR and brain region-specific RT-PCR. (J:197153)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrna2 Mutation:  23 strains or lines available
References
Original:  J:126075 Nakauchi S, et al., Nicotine gates long-term potentiation in the hippocampal CA1 region via the activation of alpha2* nicotinic ACh receptors. Eur J Neurosci. 2007 May;25(9):2666-81
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory