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Afdntm1Mrcr
Targeted Allele Detail
Nomenclature
Symbol: Afdntm1Mrcr
Name: afadin, adherens junction formation factor; targeted mutation 1, John A Mercer
MGI ID: MGI:3525467
Synonyms: Af6-
Gene: Afdn  Location: Chr17:13760391-13905798 bp, + strand  Genetic Position: Chr17, 8.95 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57046
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neomycin cassette was inserted into exon 4. Absence of protein product was confirmed by immunohistochemistry and Western blot analysis. (J:57046)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Afdn Mutation:  7 strains or lines available
References
Original:  J:57046 Zhadanov AB, et al., Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development. Curr Biol. 1999 Aug 26;9(16):880-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory