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Targeted Allele Detail
Symbol: Wisp3tm2Mawa
Name: WNT1 inducible signaling pathway protein 3; targeted mutation 2, Matthew L Warman
MGI ID: MGI:3525361
Synonyms: Wisp3-, Wisp3lacZdeltaex3-5, Wisp3tm1Mawa
Gene: Wisp3  Location: Chr10:39150971-39163794 bp, - strand  Genetic Position: Chr10, 20.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:94500
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/SvEv
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ-neo was inserted into the Wisp3 locus, replacing exons3-5 and creating a null allele. The allele resulted in a fusion protein that has Beta-gal activity under the endogenous promoter. The Wisp3 protein is truncated immediately after the IGFBP domain, and lacks the vWF, TSP and C-terminal domains. RT-PCR of cartilage from mutants showed a lack of wild-type transcript. Beta-gal activity was confirmed in cells transfected with a vector expressing the Wisp3-lacZ fusion protein. (J:94500)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wisp3 Mutation:  3 strains or lines available
Original:  J:94500 Kutz WE, et al., WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol. 2005 Jan;25(1):414-21
All:  2 reference(s)

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The Jackson Laboratory