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Targeted Allele Detail
Symbol: Ccn6tm2Mawa
Name: cellular communication network factor 6; targeted mutation 2, Matthew L Warman
MGI ID: MGI:3525361
Synonyms: Wisp3-, Wisp3lacZdeltaex3-5, Wisp3tm1Mawa
Gene: Ccn6  Location: Chr10:39150970-39163794 bp, - strand  Genetic Position: Chr10, 20.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:94500
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/SvEv
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ-neo was inserted into the Wisp3 locus, replacing exons3-5 and creating a null allele. The allele resulted in a fusion protein that has Beta-gal activity under the endogenous promoter. The Wisp3 protein is truncated immediately after the IGFBP domain, and lacks the vWF, TSP and C-terminal domains. RT-PCR of cartilage from mutants showed a lack of wild-type transcript. Beta-gal activity was confirmed in cells transfected with a vector expressing the Wisp3-lacZ fusion protein. (J:94500)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccn6 Mutation:  2 strains or lines available
Original:  J:94500 Kutz WE, et al., WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol. 2005 Jan;25(1):414-21
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory