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Pf4tm1Mako
Targeted Allele Detail
Nomenclature
Symbol: Pf4tm1Mako
Name: platelet factor 4; targeted mutation 1, M Anna Kowalska
MGI ID: MGI:3525230
Synonyms: mPF4-
Gene: Pf4  Location: Chr5:90772435-90773381 bp, + strand  Genetic Position: Chr5, 44.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94900
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll three exons were replaced with a neomycin resistance gene. RT-PCR and immunoblot confirmed the lack of transcript and protein, respectively, from mutant plateles. (J:94900)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pf4 Mutation:  4 strains or lines available
Notes
ES Cell Line = 129/SvJ ES cells, GENOMESYSTEMS, Inc

References
Original:  J:94900 Eslin DE, et al., Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin. Blood. 2004 Nov 15;104(10):3173-80
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory