Tg(Pbsn-Trp53*R172L)7856Ng
Transgene Detail

Summary

• Symbol: Tg(Pbsn-Trp53*R172L)7856Ng
• Name: transgene insertion 7856, Norman M Greenberg
• MGI ID: MGI:3525002
• Synonyms: PB-p53^R172L
• Transgene: Tg(Pbsn-Trp53*R172L)7856Ng Location: unknown
• Alliance: Tg(Pbsn-Trp53*R172L)7856Ng page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pbsn-Trp53*R172L)7856Ng expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trp53 (MGI:98834)	Transgene codes for a protein with an arginine to leucine mutation.

• Mutation details: The rat probasin promoter drove the expression of a murine Trp53 sequence containing an arginine to leucine mutation at codon 172. The polyA sequence was donated by SV40. RT-PCR detected transgene expression in the prostate, brain and spleen, but not in the bladder, kidney, testis, lung, heart, seminal vessicle, liver or coagulating gland. Expression levels were said to be subphysiological. (J:87255)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:87255 Hernandez I, et al., Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival. Mol Cancer Res. 2003 Dec;1(14):1036-47
• All: 1 reference(s)