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Targeted Allele Detail
Symbol: Itgb4tm2Fgg
Name: integrin beta 4; targeted mutation 2, Filippo G Giancotti
MGI ID: MGI:3524974
Synonyms: beta41355T, beta4-1355T, Itgb4-
Gene: Itgb4  Location: Chr11:115974725-116008412 bp, + strand  Genetic Position: Chr11, 80.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:94627
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert the Itgb4 cytoplasmic domain up to amino acid 1355, a stop codon, an SV40 pA signal, and a neo immediately downstream of the exon encoding the transmembrane segment of the protein. Immunoprecipitation and FACS analysis on primary karatinocytes indicated that the mutant protein is expressed at the cell surface. (J:94627)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb4 Mutation:  81 strains or lines available
Original:  J:94627 Nikolopoulos SN, et al., Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell. 2004 Nov;6(5):471-83
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory