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Macroh2a1tm1Peh
Targeted Allele Detail
Nomenclature
Symbol: Macroh2a1tm1Peh
Name: macroH2A.1 histone; targeted mutation 1, John R Pehrson
MGI ID: MGI:3522572
Synonyms: macroH2A1-
Gene: Macroh2a1  Location: Chr13:56073622-56135626 bp, - strand  Genetic Position: Chr13, 30.06 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121382
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRESBgeo cassette was inserted in 1st intron. This cassette was flanked by LoxP sites and a 3rd loxP site was inserted in the 2nd intron. Transient cre expression removed the floxed sequence, including exon 2, which encodes the first part of the H2A domain. Western blot analysis confirmed the absence of protein product. (J:121382)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Macroh2a1 Mutation:  44 strains or lines available
Notes
ES cell line = 98-2 (Incyte Genomics; "129svJ").
References
Original:  J:121382 Changolkar LN, et al., Developmental changes in histone macroH2A1-mediated gene regulation. Mol Cell Biol. 2007 Apr;27(7):2758-64
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory