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Ovol2tm1Xdai
Targeted Allele Detail
Summary
Symbol: Ovol2tm1Xdai
Name: ovo like zinc finger 2; targeted mutation 1, Xing Dai
MGI ID: MGI:3522498
Gene: Ovol2  Location: Chr2:144147095-144174000 bp, - strand  Genetic Position: Chr2, 70.99 cM, cytoband H1
Alliance: Ovol2tm1Xdai page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106405
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1a, 1b and 2 were replaced with a cassette containing an EGFP and a PGK-neo cassette so that EGFP expression would be controled by the endogenous promoter region. EGFP expression was detected in the inner cell mass of blastocysts and later in the epiblast but not the extraembryonic region of E6.5 embryos. (J:106405)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 80 assay results
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ovol2 Mutation:  22 strains or lines available
References
Original:  J:106405 Mackay DR, et al., The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol. 2006 Mar 1;291(1):38-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory