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Targeted Allele Detail
Symbol: Dctn1tm1Cai
Name: dynactin 1; targeted mutation 1, Huaibin Cai
MGI ID: MGI:3522484
Synonyms: Dctn1m
Gene: Dctn1  Location: Chr6:83165920-83200117 bp, + strand  Genetic Position: Chr6, 35.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:129269
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsNucleotide substitutions (GGGC to CTGA) in exon 2 introduced an amino acid substitution of a serine for a glycine at position 59 (G59S). A loxP site was inserted into intron 1 and a floxed neo cassette was also inserted into intron 3 and subsequently removed by cre-mediated recombination. (J:129269)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dctn1 Mutation:  37 strains or lines available
Original:  J:129269 Lai C, et al., The G59S mutation in p150(glued) causes dysfunction of dynactin in mice. J Neurosci. 2007 Dec 19;27(51):13982-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory