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Kcnn1tm1.1Jpad
Targeted Allele Detail
Nomenclature
Symbol: Kcnn1tm1.1Jpad
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; targeted mutation 1.1, John P Adelman
MGI ID: MGI:3522422
Synonyms: SK1delta
Gene: Kcnn1  Location: Chr8:70842049-70863258 bp, - strand  Genetic Position: Chr8, 34.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94941
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted 40 nucleotides 5' of the initiation methionine codon in exon 3 and a floxed neomycin resistance gene as well as an EGFP gene were inserted in the intron between exons 5 and 6. Crossing to cre-deleter mice led to the excision of the coding portion of exon 3, exon 4 and exon 5 as well as the neo resistance gene. RT-PCR and western blot analysis confirmed the absence of transcription and translation. The EGFP insert was non functional. (J:94941)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnn1 Mutation:  3 strains or lines available
References
Original:  J:94941 Bond CT, et al., Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J Neurosci. 2004 Jun 9;24(23):5301-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory