Serpine2^tm2Dmn
Targeted Allele Detail

Summary

• Symbol: Serpine2^tm2Dmn
• Name: serine (or cysteine) peptidase inhibitor, clade E, member 2; targeted mutation 2, Denis Monard
• MGI ID: MGI:3522355
• Synonyms: PN-1^HAPN-1-lacZ, PN-1 KI
• Gene: Serpine2 Location: Chr1:79772038-79836382 bp, - strand Genetic Position: Chr1, 40.97 cM
• Alliance: Serpine2^tm2Dmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94811
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting construct was used to replace exon 2 with the endogenous 56 bp secretion signal sequence upstream of a hemagglutinin-tagged mature Serpine2 1137 bp cDNA sequence. Downstream of this were IRES-NLS-lacZ-pA and TK-neo-pA cassettes. By staining, expression profiles of Beta-galactosidase in sagittal sections were as expected as activity was under the control of the Serpine2 regulatory sequences. (J:94811)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpine2 Mutation: 25 strains or lines available

References

• Original: J:94811 Kvajo M, et al., Regulation of brain proteolytic activity is necessary for the in vivo function of NMDA receptors. J Neurosci. 2004 Oct 27;24(43):9734-43
• All: 7 reference(s)