Tg(Tyrp1-Fgfr1*IIIc)3Sjav
Transgene Detail

Summary

• Symbol: Tg(Tyrp1-Fgfr1*IIIc)3Sjav
• Name: transgene insertion 3, Sophie Javerzat
• MGI ID: MGI:3522205
• Synonyms: FGFR1-DN, tyrp1-FGFR-DN
• Transgene: Tg(Tyrp1-Fgfr1*IIIc)3Sjav Location: unknown
• Alliance: Tg(Tyrp1-Fgfr1*IIIc)3Sjav page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F2

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A dominant-negative murine Fgf receptor derived from the Ffgr1 splice variant IIIc was flanked by enhancer sequences from a rabbit Beta globin intron and polyA sequence from the human growth hormone gene. This construct was then cloned downstream of the Tyrosinase related protein-1 (Tyrp1) promoter. A high degree of transgene expression was detected in the retinal pigment epithelium by E10.5, but was not detected in the melanocytic lineage prior to cells becoming fully differentiated and pigmented. Eyes showed morphological abnormalities and a gross reduction in size. (J:64993)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tyrp1-Fgfr1*IIIc)3Sjav

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:64993 Rousseau B, et al., Neural and angiogenic defects in eyes of transgenic mice expressing a dominant-negative FGF receptor in the pigmented cells. Exp Eye Res. 2000 Oct;71(4):395-404
• All: 2 reference(s)