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Targeted Allele Detail
Symbol: Npr2tm1Gar
Name: natriuretic peptide receptor 2; targeted mutation 1, David L Garbers
MGI ID: MGI:3522129
Synonyms: Npr2-
Gene: Npr2  Location: Chr4:43631935-43651244 bp, + strand  Genetic Position: Chr4, 23.05 cM
Skeletal comparison of wild type and Npr2tm1Gar/Npr2tm1Gar mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:94718
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3-7, which encode the C-terminal half of the extracellular ligand-binding domain and the transmembrane segment, were replaced with a neo. mRNA was not detected in brains of mutant animals. (J:94718)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npr2 Mutation:  39 strains or lines available
Original:  J:94718 Tamura N, et al., Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17300-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory