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Nt5etm1Lft
Targeted Allele Detail
Nomenclature
Symbol: Nt5etm1Lft
Name: 5' nucleotidase, ecto; targeted mutation 1, Linda F Thompson
MGI ID: MGI:3522017
Synonyms: Cd73-, CD73-KO
Gene: Nt5e  Location: Chr9:88327609-88372089 bp, + strand  Genetic Position: Chr9, 47.24 cM, cytoband E3.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94697
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neo cassette in reverse orientation to transcription. Northern blot of kidneys from mutant animlas indicated a lack of transcript. (J:94697)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nt5e Mutation:  5 strains or lines available
References
Original:  J:94697 Thompson LF, et al., Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004 Dec 6;200(11):1395-405
All:  75 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory