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Targeted Allele Detail
Symbol: Del(11Cops3-Rnf112)1Jrl
Name: deletion, Chr 11, James R Lupski 1
MGI ID: MGI:3521985
Synonyms: Del(11Csn3-Zfp179)1Jrl, Del1Jrl, df(11)17
Gene: Del(11Cops3-Rnf112)1Jrl  Location: Chr11:59817795-61454131 bp  Genetic Position: Chr11, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:83302
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted
Mutation:    Intergenic deletion
  Del(11Cops3-Rnf112)1Jrl involves 78 genes/genome features (Gm20095, Gm16062, Cops3 ...) View all
Mutation detailsA deletion between Cops3 and Rnf112 was engineered in ES cells by targeted insertion of complementary partial Hprt-loxP constructs at each site. Cre recombinase actived deleted the intervening region and reconstructed the Hprt minigene for selection purposes. (J:83302)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(11Cops3-Rnf112)1Jrl Mutation:  1 strain or line available
Original:  J:83302 Walz K, et al., Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol Cell Biol. 2003 May;23(10):3646-55
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory