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Targeted Allele Detail
Symbol: Dll4tm1Nwg
Name: delta like canonical Notch ligand 4; targeted mutation 1, Nicholas W Gale
MGI ID: MGI:3521976
Synonyms: Dll4lacZ, Dll4Lz
Gene: Dll4  Location: Chr2:119325784-119335666 bp, + strand  Genetic Position: Chr2, 59.97 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:94740
Parent Cell Line:  F1H4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region was replaced with a Beta-gal neo cassette. Quantitative PCR indicated that transcript levels in heterozygotes were decreased compared to wild-type transcript levels. (J:94740)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dll4 Mutation:  17 strains or lines available
Original:  J:94740 Gale NW, et al., Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15949-54
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory