Tph2^Pro447
Spontaneous Allele Detail

Summary

• Symbol: Tph2^Pro447
• Name: tryptophan hydroxylase 2; Proline 447
• MGI ID: MGI:3521925
• Synonyms: 1473C
• Gene: Tph2 Location: Chr10:114914546-115020927 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tph2^Pro447 page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: Cytosine at position 1473 results in Proline at amino acid residue 447. This variant has been identified in 129X1/SvJ mice and C57BL/6 from Jackson Laboratory, Charles River, Harlan and Hilltop. Proline is found at this position in the proteins of human and rat as well. (J:94745)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph2 Mutation: 41 strains or lines available

References

• Original: J:94745 Zhang X, et al., Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science. 2004 Jul 9;305(5681):217
• All: 11 reference(s)