About   Help   FAQ
Targeted Allele Detail
Symbol: Apctm2.1Cip
Name: APC, WNT signaling pathway regulator; targeted mutation 2, Christine Perret
MGI ID: MGI:3521822
Synonyms: Apc2lox14, Apcfle14, Apclox, Apctm2Cpe
Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:94721
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted into intron 13 and a loxP flanked PGK-Hprt cassette into intron 14. Cre mediated recombination removed a floxed HPRT cassette that was inserted into exon 14, leaving exon 14 flanked with loxP sites. (J:94721)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  119 strains or lines available
Original:  J:94721 Colnot S, et al., Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17216-21
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.21
The Jackson Laboratory