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Apctm2.1Cip
Targeted Allele Detail
Nomenclature
Symbol: Apctm2.1Cip
Name: APC, WNT signaling pathway regulator; targeted mutation 2, Christine Perret
MGI ID: MGI:3521822
Synonyms: Apc2lox14, Apcfle14, Apclox, Apctm2Cpe
Gene: Apc  Location: Chr18:34220924-34322552 bp, + strand  Genetic Position: Chr18, 18.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94721
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into intron 13 and a loxP flanked PGK-Hprt cassette into intron 14. Cre mediated recombination removed a floxed HPRT cassette that was inserted into exon 14, leaving exon 14 flanked with loxP sites. (J:94721)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  58 strains or lines available
References
Original:  J:94721 Colnot S, et al., Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17216-21
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory