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Hoxa13tm1Jwi
Targeted Allele Detail
Nomenclature
Symbol: Hoxa13tm1Jwi
Name: homeobox A13; targeted mutation 1, Jeffrey W Innis
MGI ID: MGI:3521726
Synonyms: Hoxa13Ala28
Gene: Hoxa13  Location: Chr6:52257694-52260803 bp, - strand  Genetic Position: Chr6, 25.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94412
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsHomologous recombination was used to insert 10 additional alanine residues into repeat III, bringing the largest polyalanine sequence up to 28 residues. (J:94412)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hoxa13 Mutation:  21 strains or lines available
References
Original:  J:94412 Innis JW, et al., Polyalanine expansion in HOXA13: three new affected families and the molecular consequences in a mouse model. Hum Mol Genet. 2004 Nov 15;13(22):2841-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory