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Targeted Allele Detail
Symbol: Cysltr2tm1Ykn
Name: cysteinyl leukotriene receptor 2; targeted mutation 1, Yoshihide Kanaoka
MGI ID: MGI:3521667
Synonyms: CysLT2-, CYSLT2R KO, Cystr2-
Gene: Cysltr2  Location: Chr14:73025772-73049114 bp, - strand  Genetic Position: Chr14, 38.54 cM
Germline Transmission:  Earliest citation of germline transmission: J:94488
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of a neo into exon 6 interrupted 85% of the coding sequence. Northern blot showed a lack of transcript in mutant lung, spleen and small intestine. (J:94488)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cysltr2 Mutation:  20 strains or lines available
Original:  J:94488 Beller TC, et al., Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem. 2004 Oct 29;279(44):46129-34
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory