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Cysltr2tm1Ykn
Targeted Allele Detail
Nomenclature
Symbol: Cysltr2tm1Ykn
Name: cysteinyl leukotriene receptor 2; targeted mutation 1, Yoshihide Kanaoka
MGI ID: MGI:3521667
Synonyms: CysLT2-, CYSLT2R KO, Cystr2-
Gene: Cysltr2  Location: Chr14:73029128-73049114 bp, - strand  Genetic Position: Chr14, 38.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94488
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neo into exon 4 interrupted 85% of the coding sequence. Northern blot showed a lack of transcript in mutant lung, spleen and small intestine. (J:94488)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cysltr2 Mutation:  13 strains or lines available
References
Original:  J:94488 Beller TC, et al., Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem. 2004 Oct 29;279(44):46129-34
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory