Ntrk3tm1(cre)Lfr
Targeted Allele Detail
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Symbol: |
Ntrk3tm1(cre)Lfr |
Name: |
neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Louis F Reichardt |
MGI ID: |
MGI:3521571 |
Synonyms: |
Ntrk3tm1(cre)Rice, Ntrk3tm(cre)1Lfr |
Gene: |
Ntrk3 Location: Chr7:77825711-78228865 bp, - strand Genetic Position: Chr7, 44.01 cM
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Alliance: |
Ntrk3tm1(cre)Lfr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:94575
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Ntrk3tm1(cre)Lfr expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Ntrk3 (MGI:97385) |
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Mutation details: An IRES-Cre-SV40pA and FRT-flanked neo cassette was inserted 52 bp downstream of the stop codon into exon 18. Crossing with mice expressing Flp recombinase removed the neo. Northern blot showed expression of a shorter transcript than wild-type, indicating that the wild-type transcript contains a long 3' UTR, which was truncated by the insertion of the SV40 after the Cre.
(J:94575)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Ntrk3
(mouse)
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Original: |
J:94575 Funfschilling U, et al., TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells. J Comp Neurol. 2004 Dec 20;480(4):392-414 |
All: |
8 reference(s) |
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