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Il10tm1Roer
Targeted Allele Detail
Nomenclature
Symbol: Il10tm1Roer
Name: interleukin 10; targeted mutation 1, Axel Roers
MGI ID: MGI:3521568
Synonyms: IL-10FL
Gene: Il10  Location: Chr1:131019845-131024970 bp, + strand  Genetic Position: Chr1, 56.89 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94537
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    The insertion of loxP sites flanking exon 1 created this allele. (J:94537)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il10 Mutation:  31 strains or lines available
References
Original:  J:94537 Roers A, et al., T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med. 2004 Nov 15;200(10):1289-97
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory