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Tg(KRT14-HPV16E7)2304Plam
Transgene Detail
Nomenclature
Symbol: Tg(KRT14-HPV16E7)2304Plam
Name: transgene insertion 2304, Paul F Lambert
MGI ID: MGI:3514313
Synonyms: 2304, K14E7, K14-E7, K14E7WT, K14HPV16E7
Transgene: Tg(KRT14-HPV16E7)2304Plam  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene contains a HPV16 fragment (nt79-883) encompassing both the E6 and E7 genes along with promoter, 3'UTR and polyA sequences from human KRT14. Only E7 is expressed due to the presence of a translation termination linker in the N terminal region of the E6 gene. Transgene expression is targeted toward epithelial tissues. Mice derived from founder 2304 had 2 copies of the transgene. Mice derived from founder 2332 had 7-8 copies of the transgene. this is a representative record for lines 2304 and 2332 which have identical phenotypes. (J:86018)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:86018 Herber R, et al., Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J Virol. 1996 Mar;70(3):1873-81
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory