Tg(KRT14-HPV16E7)2304Plam
Transgene Detail

Summary

• Symbol: Tg(KRT14-HPV16E7)2304Plam
• Name: transgene insertion 2304, Paul F Lambert
• MGI ID: MGI:3514313
• Synonyms: 2304, K14E7, K14-E7, K14E7^WT, K14HPV16E7
• Transgene: Tg(KRT14-HPV16E7)2304Plam Location: unknown
• Alliance: Tg(KRT14-HPV16E7)2304Plam page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains a HPV16 fragment (nt79-883) encompassing both the E6 and E7 genes along with promoter, 3'UTR and polyA sequences from human KRT14. Only E7 is expressed due to the presence of a translation termination linker in the N terminal region of the E6 gene. Transgene expression is targeted toward epithelial tissues. Mice derived from founder 2304 had 2 copies of the transgene. Mice derived from founder 2332 had 7-8 copies of the transgene. this is a representative record for lines 2304 and 2332 which have identical phenotypes. (J:86018)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT14-HPV16E7)2304Plam

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:86018 Herber R, et al., Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J Virol. 1996 Mar;70(3):1873-81
• All: 47 reference(s)