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Vav3tm1Xrb
Targeted Allele Detail
Nomenclature
Symbol: Vav3tm1Xrb
Name: vav 3 oncogene; targeted mutation 1, Xose R Bustelo
MGI ID: MGI:3514154
Synonyms: Vav3-
Gene: Vav3  Location: Chr3:109340653-109685698 bp, + strand  Genetic Position: Chr3, 48.13 cM, cytoband G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111973
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe promoter region and half of Exon 1 were eliminated. QRT-PCR, in situ hybridization, immunohistochemistry, and Western blot analysis confirmed the absence of transcription and translation. (J:111973)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vav3 Mutation:  3 strains or lines available
Notes
ES Cell line = 0101, Lot 3/2/01
References
Original:  J:111973 Sauzeau V, et al., Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction. Nat Med. 2006 Jul;12(7):841-5
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory