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Notch1tm3(cre)Rko
Targeted Allele Detail
Nomenclature
Symbol: Notch1tm3(cre)Rko
Name: notch 1; targeted mutation 3, Raphael Kopan
MGI ID: MGI:3514150
Synonyms: N1::cre, N1::creLO, N1::cretg, N1IP-Cre, N1IP::CRELOW, NIP-Cre
Gene: Notch1  Location: Chr2:26347914-26393834 bp, - strand  Genetic Position: Chr2, 18.91 cM
Corneal plaques and increased angiogenesis in the ear of Notch1tm2Rko/Notch1tm3(cre)Rko mice

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119910
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
    The intracellular domain was replaced with cre recombinase. (J:119910)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Notch1     Summary of all recombinase alleles driven by Notch1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:  92 strains or lines available
References
Original:  J:119910 Vooijs M, et al., Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development. 2007 Feb;134(3):535-44
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory