Tg(Mpz-Nrg1)33Slca
Transgene Detail

Summary

• Symbol: Tg(Mpz-Nrg1)33Slca
• Name: transgene insertion 33, Steven L Carroll
• MGI ID: MGI:3514148
• Synonyms: P^oGGFbeta3
• Transgene: Tg(Mpz-Nrg1)33Slca Location: unknown
• Alliance: Tg(Mpz-Nrg1)33Slca page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mpz-Nrg1)33Slca expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Nrg1 (112400)

  Nrg1	(MGI:96083)

• Mutation details: This transgene expresses the rat Nrg1 varient GGFbeta3 containing a common leucine polymorphism under the control of the mouse Mpz promoter. Transgene expression is directed to Schwann cells and was detected in the sciatic nerve. (J:84874)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mpz-Nrg1)33Slca

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:84874 Huijbregts RP, et al., Hypertrophic neuropathies and malignant peripheral nerve sheath tumors in transgenic mice overexpressing glial growth factor beta3 in myelinating Schwann cells. J Neurosci. 2003 Aug 13;23(19):7269-80
• All: 1 reference(s)