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DgkdGt(RRT600)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: DgkdGt(RRT600)Byg
Name: diacylglycerol kinase, delta; gene trap RRT600, BayGenomics
MGI ID: MGI:3514143
Synonyms: DgkdGt(pGTlxf)Byg
Gene: Dgkd  Location: Chr1:87781009-87872902 bp, + strand  Genetic Position: Chr1, 44.44 cM
Mutation
origin
Mutant Cell Line:  RRT600
Germline Transmission:  Earliest citation of germline transmission: J:126380
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
 
Mutation detailsThe gene trap cassette inserted into the first intron of the gene. RT-PCR analysis indicates that expression of the long splice form is absent from the forebrain and midbrain but faint expression is seen in the cerebellum. Expression of a second splice form initiated in exon 2 is relatively unaffected. (J:126380)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dgkd Mutation:  39 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:126380 Leach NT, et al., Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. Am J Hum Genet. 2007 Apr;80(4):792-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory