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Hand1tm2Eno
Targeted Allele Detail
Nomenclature
Symbol: Hand1tm2Eno
Name: heart and neural crest derivatives expressed 1; targeted mutation 2, Eric N Olson
MGI ID: MGI:3514024
Synonyms: Hand1fx
Gene: Hand1  Location: Chr11:57828713-57832147 bp, - strand  Genetic Position: Chr11, 35.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94514
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe first exon was flanked with loxP sites via homologous recombination. An upstream FRT-flanked neo resistance cassette was removed by crossing with Tg(ACTFLPe)9205Dym transgenic mice. (J:94514)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand1 Mutation:  3 strains or lines available
References
Original:  J:94514 McFadden DG, et al., The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan;132(1):189-201
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory