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Pank2tm1Jgt
Targeted Allele Detail
Nomenclature
Symbol: Pank2tm1Jgt
Name: pantothenate kinase 2; targeted mutation 1, Jane Gitschier
MGI ID: MGI:3514020
Synonyms: Pank2-
Gene: Pank2  Location: Chr2:131262495-131299188 bp, + strand  Genetic Position: Chr2, 63.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94753
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.3 kb fragment containing half of exon 2 and part of intron 2 was replaced with a lacZ and neomycin resistance cassette driven by the polII promoter. RT-PCR and Western blot analysis confirmed the absence of transcription and translation products. (J:94753)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pank2 Mutation:  10 strains or lines available
References
Original:  J:94753 Kuo YM, et al., Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. Hum Mol Genet. 2005 Jan 1;14(1):49-57
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory