Grxcr1^{pi-Tg(Eno2-Gabrb3)0370Brll}
Transgenic Allele Detail

Summary

• Symbol: Grxcr1^{pi-Tg(Eno2-Gabrb3)0370Brll}
• Name: glutaredoxin, cysteine rich 1; transgene insertion 0370, Murray H Brilliant
• MGI ID: MGI:3513407
• Synonyms: pi^tg370, tg-370
• Gene: Grxcr1 Location: Chr5:68189178-68323741 bp, + strand Genetic Position: Chr5, 36.59 cM
• Alliance: Grxcr1^{pi-Tg(Eno2-Gabrb3)0370Brll} page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H)F2

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: This transgene expresses a mouse Gabrb3 gene under the control of the rat neural-specific enolase promoter. Expression was detected in the brain. This line exhibited behavioral defects not seen in other lines, suggesting that insertional inactivation of an endogenous gene was responsible for the phenotype. A non-complementation test demonstrated that the insertional mutation is allelic to pirouette. Further molecular analysis showed that the insertion is located in intron 2, 25 kb downstream of exon 2. (J:83131, J:93174, J:156811)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grxcr1 Mutation: 22 strains or lines available

References

• Original: J:93174 Odeh H, et al., Characterization of two transgene insertional mutations at pirouette, a mouse deafness locus. Audiol Neurootol. 2004 Sep-Oct;9(5):303-14
• All: 3 reference(s)