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Igh-Jtm1(3H9-VDJ)Mwg
Targeted Allele Detail
Nomenclature
Symbol: Igh-Jtm1(3H9-VDJ)Mwg
Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Martin Weigert
MGI ID: MGI:3513167
Synonyms: 3H9, 3H9.KI, 3H9R, 3H9 sd-tg, IgH3H9, VH3H9R, VH3H9 Tg
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94501
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe endogenous DQ52 and all four heavy chain J elements were replaced by a rearranged heavy chain V 3H9 gene encoding an H chain of anti-dsDNA antibody and a neomycin resistance gene. (J:94501)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
References
Original:  J:94501 Chen C, et al., Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity. 1995 Dec;3(6):747-55
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/03/2022
MGI 6.19
The Jackson Laboratory