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QTL Variant Detail
QTL variant: Fmgty10C57BL/6J
Name: femur geometry 10; C57BL/6J
MGI ID: MGI:3513015
QTL: Fmgty10  Location: unknown  Genetic Position: Chr12, cM position of peak correlated region/allele: 55.11 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased standard deviation of outer fiber length (StdOFL) compared to BALB/cJ. (J:94352)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures

Mapping and Phenotype information for this QTL, its variants and associated markers


487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to standard deviation of outer fiber length (StdOFL) and shape factor (SF) mapped to 52 cM on mouse Chromosome 12 near D12Mit167. This locus is designated Fmgty10. C57BL/6J-derived alleles confer increased StdOFL compared to BALB/cJ-derived alleles, and BALB/cJ-derived alleles confer increased SF compared to C57BL/6J-derived alleles.

Original:  J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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