About   Help   FAQ
QTL Variant Detail
QTL variant: Fmgty1C57BL/6J
Name: femur geometry 1; C57BL/6J
MGI ID: MGI:3512977
QTL: Fmgty1  Location: unknown  Genetic Position: Chr1, cM position of peak correlated region/allele: 50.84 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased shape factor compared to BALB/cJ. (J:94352)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures

Mapping and Phenotype information for this QTL, its variants and associated markers


487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to cortical thickness, shape factor, and standard deviation of outer fiber length (StdOFL) mapped to 59 cM on mouse Chromosome 1 near D1Nds2. This locus is designated Fmgty1 (femur geometry 1). C3H/HeJ-derived alleles confer increased cortical thickness compared to DBA/2J-derived alleles. BALB/cJ- and DBA/2J-derived alleles confer increased StdOFL compared to C57BL/6J- and C3H/HeJ-derived alleles. C57BL/6J- and C3H/HeJ-derived alleles confer increased shape factor compared to BALB/cJ- and DBA/2J-derived alleles.

Original:  J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory