Tg(HBVX)11Gja
Transgene Detail

Summary

• Symbol: Tg(HBVX)11Gja
• Name: transgene insertion 11, Gilbert Jay
• MGI ID: MGI:3512672
• Synonyms: C11, HBx C11
• Transgene: Tg(HBVX)11Gja Location: unknown
• Alliance: Tg(HBVX)11Gja page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 1.15 kb fragment of HBV subtype adr spanning nucleotides 707-1856 in the viral genome was microinjected into fertilized eggs of CD-1 mice. This DNA fragment contained the entire coding region of the HBx gene, transcriptional enhancer, principal RNA start sites and a polyA site. Northern blot analysis detected transgene expression in the liver, kidney, and the testis. This particular transgene was associated with founder C11. (J:78178)

Tumor Data

List all tumor models in MMHCdb carrying Tg(HBVX)11Gja

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78178 Kim CM, et al., HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature. 1991 May 23;351(6324):317-20
• All: 2 reference(s)