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Targeted Allele Detail
Symbol: Htra2tm1Jdo
Name: HtrA serine peptidase 2; targeted mutation 1, Julian Downward
MGI ID: MGI:3512633
Synonyms: HtrA2/Omi-
Gene: Htra2  Location: Chr6:83051266-83055273 bp, - strand  Genetic Position: Chr6, 35.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:94227
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P/Ola
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo gene replaced part of exon 1, exons 2 to 6, and part of exon 7 via homologous recombination, removing 83% of the coding sequence including the proteolytic catalytic site. Western blot analysis confirmed absence of protein in MEFs (J:94227)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htra2 Mutation:  11 strains or lines available
Original:  J:94227 Martins LM, et al., Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol. 2004 Nov;24(22):9848-62
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory