Tg(tetO-BCL6)2Bbn
Transgene Detail

Summary

• Symbol: Tg(tetO-BCL6)2Bbn
• Name: transgene insertion 2, Beverly Baron
• MGI ID: MGI:3512423
• Transgene: Tg(tetO-BCL6)2Bbn Location: unknown
• Alliance: Tg(tetO-BCL6)2Bbn page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A human BCL6 gene is expressed by this transgene. Transcription is directed by a tetracycline-responsive promoter element (tetO). When bred with another transgenic mouse expressing tetracycline-controlled transactivator protein (tTA) to create a bitransgenic animal, BCL6 expression can be regulated with the tetracycline analog, doxycycline. This line of mice had approximately 20 copies of the transgene. (J:93391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93391 Baron BW, et al., The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14198-203
• All: 3 reference(s)