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Txnrd2tm1.1Marc
Targeted Allele Detail
Nomenclature
Symbol: Txnrd2tm1.1Marc
Name: thioredoxin reductase 2; targeted mutation 1.1, Marcus Conrad
MGI ID: MGI:3512409
Synonyms: TrxR2-
Gene: Txnrd2  Location: Chr16:18426384-18479073 bp, + strand  Genetic Position: Chr16, 11.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94136
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCrossing to a cre-deleter strain resulted in excision the 4 floxed exons containing the C-terminal catalytic center. Low levels of a truncated message were detected by RT-PCR (J:94136)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Txnrd2 Mutation:  8 strains or lines available
References
Original:  J:94136 Conrad M, et al., Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 2004 Nov;24(21):9414-23
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory