Orq3^M16i
QTL Variant Detail

Summary

• QTL variant: Orq3^M16i
• Name: ovulation rate QTL 3; M16i
• MGI ID: MGI:3512231
• QTL: Orq3 Location: Chr8:32506572-71740637 bp Genetic Position: Chr8, Syntenic

Variant origin

• Strain of Specimen: M16i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased ovulation rate compared to L6. (J:94028)
• Inheritance: Other (see notes)

Notes

Orq3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94028

Linkage analysis was performed on 439 pregnant female animals from a (M16i x L6)F2 intercross to identify QTLs associated with reproductive traits. Parental strain M16i exhibits a higher ovulation rate and higher number of live fetuses at 10 weeks of gestation compared to L6, but parental strain L6 exhibits increased total fetal survival rate compared to M16i.

On mouse Chromosome 8, linkage to ovulation rate mapped to 24.9 cM (Orq3, LOD=3.4) and 46.3 cM (Orq1, LOD=3.5). The QTL interval of Orq3 (ovulation rate QTL 3) spans 14 cM - 33 cM and is flanked by markers D8Mit4 and D8Mit31. The QTL interval of Oriq1 spans 33 cM - 55.5 cM and is flanked by markers D8Mit31 and D8Mit121. M16i-derived alleles confer additively inherited increased ovulation rate at Orq3 and Orq1.

References

• Original: J:94028 Rocha JL, et al., A large-sample QTL study in mice: III. Reproduction. Mamm Genome. 2004 Nov;15(11):878-86
• All: 1 reference(s)