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Targeted Allele Detail
Symbol: Mtortm1.1Koz
Name: mechanistic target of rapamycin kinase; targeted mutation 1.1, Sara C Kozma
MGI ID: MGI:3512186
Synonyms: mTOR-
Gene: Mtor  Location: Chr4:148448611-148557683 bp, + strand  Genetic Position: Chr4, 78.76 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:94133
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe floxed promoter and exons 1-6 region and the neo cassette were deleted upon crossing with mice expressing Cre recombinase in the germ line. Immunoblot indicated that levels of protein in heterozygote MEFs were approximately half that of wild-type MEFs. (J:94133)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtor Mutation:  11 strains or lines available
Original:  J:94133 Gangloff YG, et al., Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol. 2004 Nov;24(21):9508-16
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory