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Ptpn11tm5Bgn
Targeted Allele Detail
Nomenclature
Symbol: Ptpn11tm5Bgn
Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 5, Benjamin Neel
MGI ID: MGI:3512153
Synonyms: Ptpn11tm1Yan, Shp2 Ex2*
Gene: Ptpn11  Location: Chr5:121268596-121329460 bp, - strand  Genetic Position: Chr5, 61.72 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106624
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
    Ex2 is replaced with a splice acceptor(SA)/beta-gal pGK/Neo cassette. (J:106624)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:  35 strains or lines available
References
Original:  J:106624 Yang W, et al., An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev Cell. 2006 Mar;10(3):317-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory