About   Help   FAQ
Targeted Allele Detail
Symbol: Timp1tm1Pds
Name: tissue inhibitor of metalloproteinase 1; targeted mutation 1, Paul D Soloway
MGI ID: MGI:3512125
Synonyms: Timp1-, TIMP-1-, TIMP1KO, TIMP-1KO, Timp1tm1Jae
Gene: Timp1  Location: ChrX:20870166-20874735 bp, + strand  Genetic Position: ChrX, 16.38 cM
Germline Transmission:  Earliest citation of germline transmission: J:43744
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin-thymidine kinase expression cassette resulted in a duplication of part of the gene (the second through the fifth coding exons, with the duplicated copies separated by the selectable markers), and inserted into the third coding exon a 21 bp sequence that placed a stop codon in each reading frame. Northern blot analyses failed to detect transcripts from this allele in lung, ovaries or embryonic fibroblasts. (J:43744, J:94836)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Timp1 Mutation:  10 strains or lines available
Original:  J:43744 Soloway PD, et al., Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host. Oncogene. 1996 Dec 5;13(11):2307-14
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory